The Development of Strategies for the Effective Monitoring of Veterinary Drug Residues in Livestock and Livestock Products in Developing Countries

Objective:

To assist Member States to develop appropriate, effective and sustainable strategies for the monitoring of veterinary drug residues in livestock and livestock products to facilitate trade between developing and developed countries through:

  • development of appropriate sampling protocols that will meet international requirements for the detection of a range of veterinary drug residues;
  • identification, development, standardization and validation of suitable screening assays;
  • identification of appropriate confirmatory assays and, where possible, external accredited laboratories to perform the confirmation, for each of the selected compounds;
  • development of appropriate laboratory quality assurance procedures for residues monitoring.

Activities:

The project will progress in three stages:

Phase 1 – Development and validation of methods
The first Research Co-ordination meeting (RCM) will be held in Vienna from 2 to 6 September 2002. At this meeting, the participants will agree upon specific analytical techniques to be used for selected compounds and matrices. The main techniques considered will be ELISA, RIA, HPLC and biosensor assays. Phase 1 will continue with the development or adaptation, introduction and validation of these methods by the Research Contract Holders (RCHs). Research Agreement Holders (RAHs) will contribute to the initial method development and reagent supply. In the longer term a strategy will be formulated for the international, regional or national supply of kits or reagents to meet future testing needs.

Phase 2 - Formulation of sampling plans
Phase 2 will focus on the formulation of frameworks for sampling schemes for livestock and livestock products, based on the requirements of the major trading partners of each participating country and taking into consideration the principles of HACCP. The frameworks will be developed into sampling protocols containing details of sample numbers, matrices, distribution and sampling points. Details on procedures to preserve the traceability and security of the samples will be included. Routine testing of the samples using the methods validated in Phase 1 will commence.

Phase 3 – Quality Assurance
Internal and external quality assurance procedures, based on the requirements of ISO/IEC 17025 and GLP, will be implemented, including laboratory proficiency testing and the production of standard operating procedures for laboratory procedures and methods. The documentation and procedures developed should provide an excellent basis for future accreditation of each laboratory.
The CRP should result in a series of protocols for sampling livestock/products, validated methods using various techniques for a range of veterinary drug residues and a series of quality assurance procedures in accordance with international standards.

Participants:

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Reports: