Applied Radiation Biology and Radiotherapy (ARBR)

Co-ordinated Research Projects

CRP Number: E3.10.07
CRP Title: Instructive Surfaces and Scaffolds for Tissue Engineering Using Radiation Technology. (conducted jointly with F23030)
Objective: The major aim of the project is to engineer instructive scaffolds and surfaces using radiation technology to create tissues from the body’s cells (autologous and allogeneic cells) to provide tissue grafts and decrease the need for human donors.
Number of RCMs: 3
Next RCM: 2015
Year of Commencement: 2014
Number of Contract/Agreement Holders: 16 (planned)
Details

CRP Number: E3.30.36
CRP Title: Randomized Phase III Clinical Trial of Stereotactic Body Radiation Therapy Versus Transarterial Chemoembolization in Hepatocellular Carcinoma
Objective: To demonstrate equivalence/superiority of SBRT given upfront over TACE in terms of any disease progression in previously untreated patients with HCC
Number of RCMs: 4
Next RCM: 2014
Year of Commencement: 2014
Number of Contract/Agreement Holders: 12

CRP Number: E3.30.37
CRP Title: Evidence-Based Assessment of Radiotherapy Demand and Quality of Radiotherapy Services
Objective: To estimate the optimal and actual radiotherapy utilization (RTU) rates in developing countries using an evidence-based methodology; to assess the quality of radiotherapy services in the CIS region countries using a validated set of quality indicators.
Number of RCMs: 3
Next RCM: 2014
Year of Commencement: 2014
Number of Contract/Agreement Holders: 21 (planned)

CRP Number: E3.30.38
CRP Title: Radiation Therapy Planning of Non-Small Cell Lung Cancer based on PET/CT (Radiation Oncology component).
Objective: To improve the clinical outcomes of patients with NSCLC in Member States by the use of PET/CT in radiation therapy planning. This will be achieved by using a two phase design CRP. The first phase will measure baseline clinical outcomes and baseline target volume definition and then harmonise PET/CT based target volume definition. Phase two will measure clinical outcomes following the introduction of standardised PET/CT based radiotherapy treatment planning. Primary endpoint- 2-year overall survival.
Number of RCMs: 3
Next RCM: 2014
Year of Commencement: 2014
Number of Contract/Agreement Holders: 26

CRP Number: E3.50.08
CRP Title: Strengthening of “Biological Dosimetry” in IAEA Member States: Improvement of Current Techniques and Intensification of Collaboration and Networking among the Different Institutes
Objective: The major aim of the project is to increase the preparedness of biological dosimetry laboratories/institutes in IAEA Member States to react on radiation/nuclear accidents nationally and in the region.
Number of RCMs: 3
Next RCM: 2015
Year of Commencement: 2012
Number of Contract/Agreement Holders: 25
Details

CRP Number: E3.10.06
CRP Title: Safety and Optimisation of Radiation Sterilization in Tissue Banking: Studies on Functional Properties of Irradiated Tissue Grafts
Objective: Three major aims of the project are (1) to find the optimal radiation dose and processing methods for several tissues providing allograft sterility without compromising tissue biological or structural function for clinical use; (2) to facilitate research and disseminate research results in IAEA Member States to study radiation-induced effects on tissue grafts processed and preserved by different methods and; (3) to initiate collaboration between relevant laboratories, establishing of exchange programmes and joint applications for future additional funding will be stimulated.
Number of RCMs: 3
Next RCM: 2014
Year of Commencement: 2010
Number of Contract/Agreement Holders: 16
Details

CRP Number: E3.30.35
CRP Title: Resource Sparing Curative Radiotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck
Objective: To improve policies in MS concerning radiotherapy and cancer treatment for HNSCC, and ensuring effective and efficient utilization of current and future advanced cancer radiotherapy treatment technologies
Number of RCMs: 4
Next RCM: 2015
Year of Commencement: 2010
Number of Contract/Agreement Holders: 12
Details

CRP Number: E3.30.34
CRP Title: Resource Sparing Curative Treatment for Rectal Cancer
Objective: To establish the resectability rate of two different fractionation schedules in the preoperative treatment of unresectable rectal cancer
Number of RCMs: 3
Year of Commencement: 2009
Number of Contract/Agreement Holders: 9
Details

CRP Number: E3.30.31
CRP Title: Optimization of Radiotherapy in Low Resource Settings: Paediatric Cancer Patients
Objective: To enhance Member States capabilities to establish sound policies concerning radiotherapy and cancer treatment, and ensuring effective and efficient utilization of current and future advanced cancer radiotherapy treatment technologies.
Number of RCMs: 1
Year of Commencement: 2008
Number of Contract/Agreement Holders: 16
Details

CRP Number: E3.30.33
CRP Title: Short Course Versus Standard Course Radiotherapy, in Elderly and/or Fragile Patients with Glioblastoma Multiforme (GBM)
Objective: A new CRP is to optimize the treatment of elderly and/or frail patients with GBM. They will include patients >65 years of age and a KPS of 50-100 as well as those <65 years of age and a KPS of 50-70. This objective will be achieved by comparing survival after more protracted fractionated RT regimen elderly and/or frail patients with GBM to that obtained with shorter fractionated RT regimen.
Number of RCMs: 3
Year of Commencement: 2008
Number of Contract/Agreement Holders: 14
Details

CRP Number: E3.30.30
CRP Title: Altered Fractionation and Radio-sensitisation in Head and Neck Cancer Radiotherapy
Objective: To enhance Member States capabilities to establish sound policies concerning radiotherapy and cancer treatment, and ensuring effective and efficient utilization of current and future advanced cancer radiotherapy treatment technologies
Number of RCMs: 2
Year of Commencement: 2008
Number of Contract/Agreement Holders: 11
Details

CRP Number: E3.30.28
CRP Title: Investigation of Optimal Radiotherapy Regimen and Type of Irradiation in Treatment of Painful Bone Metastasis
Objective: To test two different fractionation regimens in patients with painful single or multiple bone metastasis. To test one or two single fraction re-irradiations in patients with bone metastasis. To gather knowledge about quality of life of such patients after the use of radiotherapy.
Number of RCMs: 3
Year of Commencement: 2007
Number of Contract/Agreement Holders: 15
Details

CRP Number: E3.30.26
CRP Title: Clinical/Radiobiological Study on Viral-induced Cancers' Response to Radiotherapy with Comprehensive Morbidity Assessment
Objective: To optimize the data capture, provide more details of normal tissue outcomes following cancer treatments in developing countries and validate this approach using patients participating in CRP (E3.30.24).
Number of RCMs: 3
Year of Commencement: 2006
Number of Contract/Agreement Holders: 7
Details