Applied Radiation Biology and Radiotherapy
Operational Co-ordinated Research Projects
CRP Number: E3.30.28
CRP Title: Investigation of Optimal Radiotherapy Regimen and Type of Irradiation in Treatment of Painful Bone Metastasis
Objective: To test two different fractionation regimens in patients with painful single or multiple bone metastasis.
To test one or two single fraction re-irradiations in patients with bone metastasis.
To gather knowledge about quality of life of such patients after the use of radiotherapy.
Number of RCMs: 1
Next RCM: 2008
Year of Commencement: 2007
Number of Contract Holders: 10
CRP Number: E3.30.29
CRP Title: Radiotherapy and Chemotherapy in Advanced Non-Small Cell Lung Cancer
Objective: To study the efficacy of high-dose palliative thoracic radiotherapy of 39 Gy in 13 daily fractions compared to a 2-3 cycles of chemotherapy followed by a low-dose palliative thoracic radiotherapy of either 10 Gy in a single fraction or 16 Gy in two fractions given with one week split in patients with locally advanced NSCLC (Study A).
To compare a low-dose palliative thoracic radiotherapy of either 10 Gy in a single fraction or 16 Gy in two fractions given with one week split against 2-3 cycles of chemotherapy, radiotherapy being followed by the same chemotherapy in patients with metastatic NSCLC (Study B).
To compare toxicity between the two regimens investigated for both locally advanced and metastatic NSCLC (Study A and Study B).
To assess differences in quality of life between the two regimens investigated for both locally advanced and metastatic NSCLC (Study A and Study B).
Number of RCMs: None
Next RCM: 2008
Year of Commencement: 2007
Number of Contract Holders: 14
CRP Number: E3.30.27
CRP Title: Improving Outcomes in Radiotherapy Using New Strategies of Treatment Delivery with Focus on Oesophageal Cancer
Objective: To determine if a shorter regime of EBRT in higher daily doses (4 Gy x 5 treatments) in 1 week combined with HDR BT gives equal palliation as a more protracted course of EBRT (3 Gy x 10 treatments) in 2 weeks using lower daily doses, combined with the same HDR BT doses, in the management of advanced oesophagus cancer. This would allow more patients to be treated using the same equipment and resources, with a saving also in patient hospitalisation times.
Number of RCMs: 1
Next RCM: 2009
Year of Commencement: 2006
Number of Contract Holders: 8
CRP Number: E3.30.26
CRP Title: Clinical/Radiobiological Study on Viral-induced Cancers' Response to Radiotherapy with Comprehensive Morbidity Assessment
Objective: To optimize the data capture, provide more details of normal tissue outcomes following cancer treatments in developing countries and validate this approach using patients participating in the ongoing CRP (E3.30.24).
Number of RCMs: 1
Next RCM: 2008
Year of Commencement: 2006
Number of Contract Holders: 8
CRP Number: E3.30.25
CRP Title: Resource Sparing Curative Treatment in Breast Cancer
Objective: To improve the outcomes of treatment for patients with advanced breast cancer in developing countries. This objective will be achieved by exploring the optimisation of treatment techniques which are effective, safe and resource-sparing.
Number of RCMs: 1
Next RCM: 2008
Year of Commencement: 2005
Number of Contract Holders: 10
CRP Number: E3.30.22
CRP Title: Doctoral CRP on Clinical and experimental studies to improve radiotherapy outcome in AIDS cancer patients
Objective: To develop more effective radiation therapy of cancers in AIDS cases
Number of RCMs: 3
Next RCM: 2007
Year of Commencement: 2003
Number of Contract Holders: 7
CRP Number: E3.30.23
CRP Title: Resource sparing treatment of head and neck cancer
Objective: To test a resource-sparing protocol in the management of Head & Neck cancer (Nasopharynx)
Number of RCMs: 3
Next RCM: 2007
Year of Commencement: 2003
Number of Contract Holders: 5