Nuclear Medicine
Operational Co-ordinated Research Projects
CRP Number: E1.20.16
CRP Title: Radioimmunoassay of advanced glycation end products (AGEs) in the long term management of diabetes mellitus
Objective: To develop a radioimmunoassay method for measurement of advanced glycation end products (AGEs) for monitoring of diabetes mellitus.
Number of RCMs: 1
Next RCM: -
Year of Commencement: Sep. 2000
Number of Contract Holders: 3
CRP Number: E1.30.19
CRP Title: Management of liver cancer using radionuclide methods with special emphasis on trans-arterial radioconjugate therapy and internal dosimetry
Objective: To address the problem of liver cancer by carrying out open label, prospectively randomized clinical trials to study the utility of trans-arterial radioconjugate therapy in liver cancer.
Number of RCMs: 3
Next RCM: -
Year of Commencement: Sep. 2000
Number of Contract Holders: 9
CRP Number: E1.30.26
CRP Title: Comparative evaluation of radiopharmaceuticals for radiosynovectomy
Objective: To improve the health care and quality of life of patients suffering from arthropathies due to rheumatoid arthritis or haemophiliac haemarthroses by standardizing and making available cost-effective radionuclide therapeutic procedures for widespread clinical clinical use. If the outcome of the CRP is successful, radiosynovectomy may become the first line of treatment in such patients.
Number of RCMs: 1
Next RCM: -
Year of Commencement: Oct. 2002
Number of Contract Holders: 10
Details
CRP Number: E1.30.24
CRP Title: Improvement in the treatment of acute lymphoblastic leukaemia (ALL) by the detection of minimal residual disease (MRD)
Objective: To develop prognostic algorithms to improve acute lymphoblastic leukaemia (ALL) in developing countries.
Number of RCMs: 2
Next RCM: -
Year of Commencement: Oct 2002
Number of Contract Holders: 7
CRP Number: E1.30.20
CRP Title: Intravascular radionuclide therapy (IVRNT) using beta-emitting radiopharmaceuticals for the prevention of restenosis following percutaneous trans-luminal coronary angioplasty
Objective: To identify the best therapeutic strategy using the liquid beta emitter filled in angioplasty balloons for intravascular radionuclide therapy (IVRNT) to prevent coronary artery restenosis, and to establish the use of this promising new technique in the developing countries.
Number of RCMs: 1
Next RCM: -
Year of Commencement: Nov. 2000
Number of Contract Holders: 13
CRP Number: E1.30.29
CRP Title: Evaluation of a single Utilization of Pulmonary Perfusion Scintigraphy in Patients with Suspected Pulmonary Embolism
Objective: To improve the diagnosis and management of patients with suspected pulmonary embolism by a simple radionuclide technique
Number of RCMs: 2
Next RCM: 4-7 September 2006
Year of Commencement: June 2004
Number of Contract Holders: 8
CRP Number: E1.30.28
CRP Title: Standardization and Quality control of in-house prepared radiopharmaceuticals for Nuclear Oncology
Objective: The aim would be to establish and standardise optimal in-house preparation protocols for new radio pharmacological techniques for use in the early diagnosis of cancer.
Number of RCMs: 2
Next RCM: -
Year of Commencement: June 2004
Number of Contract Holders: 6
CRP Number: E1.30.23
CRP Title: Radiopharmaceutical imaging to predict and evaluate the response of breast cancer to neo-adjuvant chemotherapy.
Objective: To determine the role of radionuclide imaging (using Tc-99m labelled lipophilic cations) in the prospective assessment of tumor response to treatment in patients with breast cancer in order to predict the outcomes of chemotherapy early in the course of treatment and to facilitate the choice of appropriate chemotherapeutic agent to optimize the quality of life and prolong disease free survival.
Number of RCMs: 2
Next RCM: -
Year of Commencement: Aug. 2001
Number of Contract Holders: 7
CRP Number: E1.30.22
CRP Title: Harmonization of protocols and procedures in the management of neonatal hydronephrosis
Objective: To develop a diagnostic algorithm and evolve a strategy for the harmonization of the various radionuclide procedures and protocols used in the management of neonatal hydronephrosis. The results of such a study may be useful in risk stratification of children with neonatal hydronephrosis and selecting the right patient at right time for surgery in order to prevent irreversible renal damage.
Number of RCMs: 2
Next RCM: -
Year of Commencement: Aug. 2001
Number of Contract Holders: 14
CRP Number: E1.30.33
CRP Title: Evaluation of the biological safety and clinical efficacy of 177 Lu-EDTMP for bone pain palliation in metastatic prostate cnacer (Phase I/II clinical trial)
Objective: The objective of this CRP is to evaluate the clinical safety and efficacy of 177Lu-EDTMP for bone pain palliation in metastatic prostate cancer in a Phase I and Phase II clinical trial.
Effective cancer management requires standardizing and coordinating treatment protocols and by making available economically affordable therapies. Our approach will utilize available capacities in to improve access to cost effective treatment by developing appropriate infrastructure, radio pharmacy and clinical institutions to promote effective use of targeted radionuclide therapy Member States. Prostate cancer is currently one of the most common malignancies worldwide. About 50-70% of patients present with locally advanced stage and about 15-30% have bone metastases at the time of diagnosis. In advanced stage of the disease, cancer spread to the skeleton occurs in a majority of patients, with skeletal metastases being predominantly osteoblastic in nature. Treatment with bone seeking beta-emitting radiopharmaceuticals has been shown to reduce pain for a prolonged period and to improve quality of life with no serious side effects. For several reasons 177Lu-EDTMP has a very good potential for use as a therapeutic agent.
Number of RCMs: 3
Next RCM: pending
Year of Commencement: 2007
Number of Contract Holders: pending
CRP Number: E1.30.32
CRP Title: Performance of rest myocardial perfusion imaging in the management of acute chest
Objective: Myocardial perfusion imaging is an emerging technique to help triage patients presenting to the emergency room with chest pain and who present with a normal or non-diagnostic electrocardiogram. The method has been shown to demonstrate a high cost saving and decrease length of stay in hospital. In essence, a
normal study allows the sage discharge of the patient from the emergency department. The purpose of our study is to extrapolate these data to the developing world and to assess the ability of this technique to predict the 30 day cardiac event rate.
Number of RCMs: 3
Next RCM: pending
Year of Commencement: 2007
Number of Contract Holders: pending
CRP Number: E1.30.31
CRP Title: Role of nuclear cardiology techniques in ischemia assessment with exercise imaging in asymptomatic diabetes
Objective: To examine the prevalence of ischemia by SPECT perfusion imaging performed during symptom limited treadmill or bicycle exercise and compare it to an age and sex-matched control group with no diabetes but with multiple coronary risk factors
Number of RCMs: 2
Next RCM: -
Year of Commencement: 2006
Number of Contract Holders: 12
CRP Number: E1.30.30
CRP Title: Development and quality control of hospital prepared radiopharmaceuticals for infection imaging for use in HIV/AIDS positive patients
Objective: To establish an armoury of infection imaging techniques with set standards and quality programme for use in HIV/AIDS positive patients
Number of RCMs: 2
Next RCM: 9-12 October 2006
Year of Commencement: 2004
Number of Contract Holders: 7
CRP Number: E1.50.19
CRP Title: Improved accuracy of molecular and immunological markers for prediction of efficacy of antimalarial drugs
Objective: To refine and validate molecular markers in the human genome that correlate with clearance of malaria parasites after specific treatment despite the drug resistant profile of the protozoan determine by molecular approach.
Number of RCMs: 2
Next RCM: 2007
Year of Commencement: 2004
Number of Contract Holders: 11
CRP Number: E1.30.27
CRP Title: Role of radionuclide techniques in the diagnosis of early dementia
Objective: To establish the role of brain perfusion SPECT in dementia in a multicenter study
Number of RCMs: 2
Next RCM: 26-29 June 2006
Year of Commencement: 2003
Number of Contract Holders: 8
CRP Number: E1.30.25
CRP Title: Nitrate augmented myocardial imaging for assessment of myocardial viability
Objective: To prospectively assess the role of nitrate-augmented Tc-99m-sestamibi myocardial SPECT in the evaluation of myocardial viability in patients with angiographically documented CAD and LV dysfunction who undergo coronary revascularization (CABG or PTCA) or receive medical therapy, in a multi-center study.
Number of RCMs: 2
Next RCM: -
Year of Commencement: 2002
Number of Contract Holders: 8
Details
CRP Number: E1.50.20
CRP Title: RCM Application of FDG-PET and Molecular Gene Profiling for Risk Stratification of Diffuse Large B-cell Non-Hodgkin’s Lymphoma in Different Ethnic Populations
Next RCM: 12 - 15 December 2006